Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid

ZHENG Yudong; WANG Yingjun; CHEN Zhonghua; CHEN Xiaofeng; WU Gang; XIE Jianxin

doi:10.13374/j.issn1001-053x.2006.01.015

Volume 28 Issue 1

Aug. 2021

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of Engineering > 2006 > 28(1): 63-67

ZHENG Yudong, WANG Yingjun, CHEN Zhonghua, CHEN Xiaofeng, WU Gang, XIE Jianxin. Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid[J]. Chinese Journal of Engineering, 2006, 28(1): 63-67. doi: 10.13374/j.issn1001-053x.2006.01.015

Citation:

ZHENG Yudong, WANG Yingjun, CHEN Zhonghua, CHEN Xiaofeng, WU Gang, XIE Jianxin. Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid[J]. Chinese Journal of Engineering, 2006, 28(1): 63-67. doi: 10.13374/j.issn1001-053x.2006.01.015

Citation:

ZHENG Yudong, WANG Yingjun, CHEN Zhonghua, CHEN Xiaofeng, WU Gang, XIE Jianxin. Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid[J]. Chinese Journal of Engineering, 2006, 28(1): 63-67. doi: 10.13374/j.issn1001-053x.2006.01.015

PDF( 880 KB)

Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid

doi: 10.13374/j.issn1001-053x.2006.01.015

1. Materials Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China;
2. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China

Received Date: 2004-11-24
Rev Recd Date: 2005-03-22

Available Online: 2021-08-24

Abstract

Abstract

Three kinds of porous composites based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and bioactive glass (BG), tricalcium phosphate (TCP), hydroxyapatite (HA) respectively were prepared for born tissue engineering scaffolds. The chemical reactions and in vitro degradation of PHBV/ BG, PHBV/TCP and PHBV/HA porous materials under physiological condition were assessed and compared. The changes in surface micromorphology, composition and structure of the composite scaffolds were investigated before and after immersed in simulated body fluid (SBF) solution. It was found that biodegradation occurred for three kinds of scaffolds which led to the weight loss of the scaffolds after immersed in SBF solution. The biomineralized reaction and ion exchange reaction occurred in PHBV/BG and PHBV/ TCP scaffolds in SBF solution, and the mineralized layer formed on the surface of those scaffolds which was analyzed as hydroxyl carbonate apatite (HCA). There was little biomineralized reaction appeared on PHBV/HA scaffolds during immersed in SBF sulotion.
- biomineralization,
- polyhydroxyalkonate,
- bioactive glass,
- β-tricalcium phosphate,
- hydroxyapatite,
- simulated body fluid