Biomineralization of three kinds of porous composites for bone tissue engineering scaffolds in simulated body fluid
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摘要: 采用生物活性玻璃(BG)、磷酸三鈣(TCP)、羥基磷灰石(HA)等生物活性陶瓷與3-羥基丁酸酯-3-羥基戊酸酯的共聚物(PHBV)復合,制備了性能良好的骨組織工程支架材料,分析了PHBV/BG,PHBV/TCP,PHBV/HA三種復合多孔支架在模擬生理溶液中的一系列化學反應,以及多孔材料在模擬生理溶液中浸泡后的成分、結構和微觀形貌的變化。研究結果表明,三種復合支架材料在模擬生理溶液中發生了降解反應而失重；PHBV/BG和PHBV/TCP在模擬生理溶液中還發生了生物礦化反應,在表面形成礦化沉積層,為具有骨生物活性的結晶態類骨碳酸羥基磷灰石；而PHBV/HA在模擬生理溶液中沒有明顯的生物活性反應。Abstract: Three kinds of porous composites based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and bioactive glass (BG), tricalcium phosphate (TCP), hydroxyapatite (HA) respectively were prepared for born tissue engineering scaffolds. The chemical reactions and in vitro degradation of PHBV/ BG, PHBV/TCP and PHBV/HA porous materials under physiological condition were assessed and compared. The changes in surface micromorphology, composition and structure of the composite scaffolds were investigated before and after immersed in simulated body fluid (SBF) solution. It was found that biodegradation occurred for three kinds of scaffolds which led to the weight loss of the scaffolds after immersed in SBF solution. The biomineralized reaction and ion exchange reaction occurred in PHBV/BG and PHBV/ TCP scaffolds in SBF solution, and the mineralized layer formed on the surface of those scaffolds which was analyzed as hydroxyl carbonate apatite (HCA). There was little biomineralized reaction appeared on PHBV/HA scaffolds during immersed in SBF sulotion.
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