Abstract: A shaking table testing study on a 1/20 scale model of a hybrid high-rise building with irregularity was carried out with the Fulong Building in Xiamen as the project background. In the test, the model's dynamic properties, damp ratio, as well as the reaction of acceleration and deformation in frequent earthquake, basic seismic intensity and rare earthquake of 7 degree were examined, and the cracking pattern and failure mechanism of the model were studied. The result of this test demonstrates that the frequencies of the first three modes of the model are 1.74Hz (Y direction translation), 2.28Hz (X direction translation) and 3.12Hz (over rotation), and the damp ratio corresponded to X direction and Y direction is 6.3% and 6.5% respectively. Under the function of frequent earthquake and rare earthquake, the maximum story drift angle of the prototype in X direction is 1/956 and 1/147 respectively, and in Y direction is 1/570 and 1/83 respectively. Therefore a rational arrangement of structural elements with good overall anti-seismic behavior was presented. Finally, some suggestions for the seismic design of the structure are put forward in this paper.