Abstract: According to the mass conservation law, a dynamic network model which considers interaction between solid walls and liquid molecules was established. This model is on the basis of solid-liquid intermolecular force and in combination with the distribution characteristics of pore throats in porous media. The change in pore pressure at different time steps was simulated through the model. The influences of solid-liquid intermolecular force, pore throat radius and wettability on the saturation distribution of remaining oil and the permeability curve of water flooding phase were analyzed. The results show that when considering solid-liquid intermolecular force the saturation of residual oil increases, thus interaction between rock and fluid molecules cannot be ignored in the study of porous flow in porous media.